Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats
YP Dai, S Bongalon, H Tian, SD Parks… - Vascular …, 2006 - Elsevier
Pulmonary hypertension is associated with remodeling of the smooth muscle layer of
pulmonary arteries, manifested by reduced smooth muscle cell (SMC) contractility and
enhanced motility and growth. These responses are underlied by increased dynamics of the
peripheral actin network. Thus, we hypothesized that pulmonary hypertension is associated
with upregulation of two proteins that regulate the dynamics of peripheral actin filaments, ie,
profilin and cofilin. We also analyzed the expression of LIMK2, which regulates the actin …
pulmonary arteries, manifested by reduced smooth muscle cell (SMC) contractility and
enhanced motility and growth. These responses are underlied by increased dynamics of the
peripheral actin network. Thus, we hypothesized that pulmonary hypertension is associated
with upregulation of two proteins that regulate the dynamics of peripheral actin filaments, ie,
profilin and cofilin. We also analyzed the expression of LIMK2, which regulates the actin …