HER2 as a therapeutic target in head and neck squamous cell carcinoma
NI Pollock, JR Grandis - Clinical Cancer Research, 2015 - AACR
NI Pollock, JR Grandis
Clinical Cancer Research, 2015•AACRThe majority of patients with head and neck squamous cell carcinoma (HNSCC) present
with advanced-stage disease. The current standard of care is surgery followed by adjuvant
radiotherapy with or without chemotherapy or chemoradiation alone. The addition of
cetuximab for the treatment of patients with locally advanced or recurrent/metastatic HNSCC
has improved overall survival and locoregional control; however, responses are often
modest, and treatment resistance is common. A variety of therapeutic strategies are being …
with advanced-stage disease. The current standard of care is surgery followed by adjuvant
radiotherapy with or without chemotherapy or chemoradiation alone. The addition of
cetuximab for the treatment of patients with locally advanced or recurrent/metastatic HNSCC
has improved overall survival and locoregional control; however, responses are often
modest, and treatment resistance is common. A variety of therapeutic strategies are being …
Abstract
The majority of patients with head and neck squamous cell carcinoma (HNSCC) present with advanced-stage disease. The current standard of care is surgery followed by adjuvant radiotherapy with or without chemotherapy or chemoradiation alone. The addition of cetuximab for the treatment of patients with locally advanced or recurrent/metastatic HNSCC has improved overall survival and locoregional control; however, responses are often modest, and treatment resistance is common. A variety of therapeutic strategies are being explored to overcome cetuximab resistance by blocking candidate proteins implicated in resistance mechanisms such as HER2. Several HER2 inhibitors are in clinical development for HNSCC, and HER2-targeted therapy has been approved for several cancers. This review focuses on the biology of HER2, its role in cancer development, and the rationale for clinical investigation of HER2 targeting in HNSCC. Clin Cancer Res; 21(3); 526–33. ©2014 AACR.
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