The lung is composed of two major anatomically distinct regions—the conducting airways
and gas‐exchanging airspaces. From a cell biology standpoint, the conducting airways can
be further divided into two major compartments, the tracheobronchial and bronchiolar
airways, while the alveolar regions of the lung make up the gas‐exchanging airspaces.
Each of these regions consists of distinct epithelial cell types with unique cellular
physiologies and stem cell compartments. This chapter focuses on model systems with …