Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps
H Wang, DC Do, J Liu, B Wang, J Qu, X Ke… - Journal of Allergy and …, 2018 - Elsevier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with mast cell–
mediated inflammation and heightened oxidant stress. Kynurenine (KYN), an endogenous
tryptophan metabolite, can promote allergen-induced mast cell activation through the aryl
hydrocarbon receptor (AhR). Objectives We sought to determine the role of the KYN/AhR
axis and oxidant stress in mast cell activation and the development of CRSwNP. Methods
We measured the expression of indoleamine 2, 3-dioxygenase 1, tryptophan 2, 3 …
mediated inflammation and heightened oxidant stress. Kynurenine (KYN), an endogenous
tryptophan metabolite, can promote allergen-induced mast cell activation through the aryl
hydrocarbon receptor (AhR). Objectives We sought to determine the role of the KYN/AhR
axis and oxidant stress in mast cell activation and the development of CRSwNP. Methods
We measured the expression of indoleamine 2, 3-dioxygenase 1, tryptophan 2, 3 …
