Increased cell motility and survival are important hallmarks of metastatic tumor cells.
However, the mechanisms that regulate the interplay between these cellular processes
remain poorly understood. In these studies, we demonstrate that CCL2, a chemokine well
known for regulating immune cell migration, plays an important role in signaling to breast
cancer cells. We report that in a panel of mouse and human breast cancer cell lines CCL2
enhanced cell migration and survival associated with increased phosphorylation of Smad3 …