[HTML][HTML] Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity

M Emara, PJ Royer, Z Abbas, HF Sewell… - Journal of Biological …, 2011 - ASBMB
Dendritic cells are professional antigen-presenting cells that are specialized in antigen
uptake and presentation. Allergy to cat has increased substantially in recent years and has
been shown to be positively associated with asthma. We have recently shown that the
mannose receptor (MR), a C-type lectin expressed by dendritic cells, recognizes various
glycoallergens from diverse sources and is involved in promoting allergic responses to a
major house dust mite allergen in vitro. Here we investigated the potential role of MR in …