SOCS3 expression is inversely correlated with Pyk2 in non-small cell lung cancer and exogenous SOCS3 inhibits proliferation and invasion of A549 cells

S Zhang, W Wang, E Wang, X Qiu - Pathology, 2012 - Elsevier
Aims We have confirmed that suppressor of cytokine signalling 3 (SOCS3) is silenced and
proline-rich tyrosine kinase 2 (Pyk2) is over-expressed in non-small cell lung cancer
(NSCLC). The aim of this study was to investigate the correlation of SOCS3 and Pyk2
expression in NSCLC, and the effects of SOCS3 up-regulation on A549 cells. Methods One
hundred cases of NSCLC were detected for the expression of SOCS3 and Pyk2 by
immunohistochemistry. The expression of SOCS3 and Pyk2 were also examined in human …