Endothelial activation in ARDS

GA Zimmerman, KH Albertine, HJ Carveth, EA Gill… - Chest, 1999 - journal.chestnet.org
Endothelial injury is often identified as a hallmark of ARDS. 1–6 Yet endothelial cells may be
altered in other ways besides frank injury in ARDS and in other pathologic syndromes. A
major concept in vascular biology that has largely evolved since the time of the original
description of ARDS is that endothelial cells can become activated and that this can occur
independently of, or as a component or consequence of, cellular injury. 7, 8 Endothelial
activation is now considered by some clinicians and investigators to be a principal …