[HTML][HTML] Structure guided chemical modifications of propylthiouracil reveal novel small molecule inhibitors of cytochrome b5 reductase 3 that increase nitric oxide …
MM Rahaman, FG Reinders, D Koes… - Journal of Biological …, 2015 - ASBMB
NADH cytochrome b 5 reductase 3 (CYB5R3) is critical for reductive reactions such as fatty
acid elongation, cholesterol biosynthesis, drug metabolism, and methemoglobin reduction.
Although the physiological and metabolic importance of CYB5R3 has been established in
hepatocytes and erythrocytes, emerging investigations suggest that CYB5R3 is critical for
nitric oxide signaling and vascular function. However, advancement toward fully
understanding CYB5R3 function has been limited due to a lack of potent small molecule …
acid elongation, cholesterol biosynthesis, drug metabolism, and methemoglobin reduction.
Although the physiological and metabolic importance of CYB5R3 has been established in
hepatocytes and erythrocytes, emerging investigations suggest that CYB5R3 is critical for
nitric oxide signaling and vascular function. However, advancement toward fully
understanding CYB5R3 function has been limited due to a lack of potent small molecule …