Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infection
F Wolter, A Glässner, B Krämer, P Kokordelis… - Journal of …, 2015 - Elsevier
Background & Aims Natural killer (NK) cells have been shown to exert anti-viral as well as
anti-fibrotic functions in hepatitis C virus (HCV) infection. Previous studies, however,
analyzed NK cell functions exclusively under atmospheric oxygen conditions despite the fact
that the liver microenvironment is hypoxic. Here, we analyzed the effects of low oxygen
tension on anti-viral and anti-fibrotic NK cell activity. Methods Peripheral (n= 34) and
intrahepatic (n= 15) NK cells from HCV (+) patients as well as circulating NK cells from …
anti-fibrotic functions in hepatitis C virus (HCV) infection. Previous studies, however,
analyzed NK cell functions exclusively under atmospheric oxygen conditions despite the fact
that the liver microenvironment is hypoxic. Here, we analyzed the effects of low oxygen
tension on anti-viral and anti-fibrotic NK cell activity. Methods Peripheral (n= 34) and
intrahepatic (n= 15) NK cells from HCV (+) patients as well as circulating NK cells from …