Regulation of ligands for the NKG2D activating receptor
NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected
cells and participates in the genesis of several inflammatory diseases. The ligands for
NKG2D are self-proteins that are induced by pathways that are active in certain
pathophysiological states. NKG2D ligands are regulated transcriptionally, at the level of
mRNA and protein stability, and by cleavage from the cell surface. In some cases, ligand …
as a major recognition receptor for detection and elimination of transformed and infected
cells and participates in the genesis of several inflammatory diseases. The ligands for
NKG2D are self-proteins that are induced by pathways that are active in certain
pathophysiological states. NKG2D ligands are regulated transcriptionally, at the level of
mRNA and protein stability, and by cleavage from the cell surface. In some cases, ligand …