Metabolism of the human heart: II. Studies on fat, ketone and amino acid metabolism

RJ Bing, A Siegel, I Ungar, M Gilbert - The American journal of medicine, 1954 - Elsevier
The myocardial extraction of fatty acids, ketone bodies and amino acids was measured in
thirty-three patients. The heart extracted considerable amounts of these non-carbohydrate
foodstuffs. Myocardial extraction ratios of fatty acids were particularly great after a high fat
intake, suggesting storage of fat in the heart muscle. A negative correlation between
myocardial carbohydrate and ketone utilization was observed; this finding is in accord with
the theory of substrate competition for available oxygen. During infusion of amino acids the …