[PDF][PDF] Nuclear factor-kB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan …
M Scartozzi, I Bearzi, C Pierantoni… - Journal of clinical …, 2007 - researchgate.net
Journal of clinical oncology, 2007•researchgate.net
Purpose NF-kB expression has been shown to be responsible for resistance to
antineoplastic agents and it also plays a part in the activation of the epidermal growth factor
receptor downstream signaling pathway in colorectal tumors. The aim of our analysis was to
investigate a correlation between NF-kB expression, response rate, time to progression, and
survival in advanced colorectal cancer patients receiving cetuximab and irinotecan.
antineoplastic agents and it also plays a part in the activation of the epidermal growth factor
receptor downstream signaling pathway in colorectal tumors. The aim of our analysis was to
investigate a correlation between NF-kB expression, response rate, time to progression, and
survival in advanced colorectal cancer patients receiving cetuximab and irinotecan.
Purpose
NF-kB expression has been shown to be responsible for resistance to antineoplastic agents and it also plays a part in the activation of the epidermal growth factor receptor downstream signaling pathway in colorectal tumors. The aim of our analysis was to investigate a correlation between NF-kB expression, response rate, time to progression, and survival in advanced colorectal cancer patients receiving cetuximab and irinotecan.
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