The immunosuppressive mammalian target of rapamycin inhibitor rapamycin is widely used
in solid-organ transplantation, but the effect of rapamycin on kidney disease is controversial.
This study evaluated the effect of rapamycin in the autologous phase of anti–glomerular
basement membrane (anti-GBM) glomerulonephritis. Disease was induced by
preimmunizing the animals with rabbit IgG 5 d before administration of rabbit anti-mouse
GBM antiserum. When rapamycin was started on the day of immunization (group 1), mice …