[HTML][HTML] Discovery of novel mechanisms and molecular targets for the inhibition of activated thrombin activatable fibrinolysis inhibitor
K Hillmayer, R Vancraenenbroeck, M De Maeyer… - Journal of Thrombosis …, 2008 - Elsevier
Background: Thrombin activatable fibrinolysis inhibitor (TAFI) is an important regulator of
fibrinolysis and an attractive target to develop profibrinolytic drugs. Objective: To analyze the
(inhibitory) properties of five monoclonal antibodies (mAbs) directed towards rat TAFI (ie MA-
RT13B2, MA-RT30D8, MA-RT36A3F5, MA-RT36B2 and MA-RT82F12). Methods and
results: Direct interference of the mAb with rat activated TAFI (TAFIa) activity was assayed
using a chromogenic activity assay. This revealed reductions of 79%±1%, 54%±4%, and …
fibrinolysis and an attractive target to develop profibrinolytic drugs. Objective: To analyze the
(inhibitory) properties of five monoclonal antibodies (mAbs) directed towards rat TAFI (ie MA-
RT13B2, MA-RT30D8, MA-RT36A3F5, MA-RT36B2 and MA-RT82F12). Methods and
results: Direct interference of the mAb with rat activated TAFI (TAFIa) activity was assayed
using a chromogenic activity assay. This revealed reductions of 79%±1%, 54%±4%, and …