Thrombin activatable fibrinolysis inhibitor: at the nexus of fibrinolysis and inflammation
M Colucci, N Semeraro - Thrombosis research, 2012 - Elsevier
TAFI (thrombin activatable fibrinolysis inhibitor) is the precursor of a basic carboxypeptidase
(TAFIa) with strong antifibrinolytic and anti-inflammatory activity. Compelling evidence
indicates that thrombin, either alone or in complex with thrombomodulin, is the main
physiological activator of TAFI. For this reason derangements of thrombin formation,
whatever the cause, may influence the fibrinolytic process too. Experimental models of
thrombosis suggest that TAFI may participate in thrombus development and persistence …
(TAFIa) with strong antifibrinolytic and anti-inflammatory activity. Compelling evidence
indicates that thrombin, either alone or in complex with thrombomodulin, is the main
physiological activator of TAFI. For this reason derangements of thrombin formation,
whatever the cause, may influence the fibrinolytic process too. Experimental models of
thrombosis suggest that TAFI may participate in thrombus development and persistence …
