Animal models of hemophilia and related diseases are important for the development of
novel treatments and to understand the pathophysiology of bleeding disorders in humans.
Testing in animals with the equivalent human disorder provides informed estimates of doses
and measures of efficacy, which aids in design of human trials. Many models of hemophilia
A, hemophilia B, and von Willebrand disease (VWD) have been developed from animals
with spontaneous mutations (hemophilia A dogs, rats, sheep; hemophilia B dogs; and VWD …