Hemophilic arthropathy is a form of joint disease that develops secondary to joint bleeding
and presents with synovial hypertrophy, cartilage and bony destruction. The arthropathy can
develop despite clotting factor replacement and is especially disabling in the aging
population. Pathobiological tissue changes are triggered by release of hemoglobin and iron
deposition in the joint, but the sequence of events and the molecular mechanisms resulting
in joint deterioration are incompletely understood. Treatment options other than clotting …