[HTML][HTML] Soluble thrombomodulin partially corrects the premature lysis defect in FVIII‐deficient plasma by stimulating the activation of thrombin activatable fibrinolysis …
JH Foley, ME Nesheim - Journal of Thrombosis and Haemostasis, 2009 - Elsevier
Background: Previous work by others has shown that premature clot lysis occurs in plasmas
deficient in components of the intrinsic pathway, due to a failure to activate thrombin
activatable fibrinolysis inhibitor (TAFI). This suggests the hypothesis that bleeding in
hemophilia is due not only to defective coagulation but also enhanced fibrinolysis. These
studies were carried out to quantify the extent of TAFI activation over time in normal plasma
(NP) and factor VIII deficient plasma (FVIII‐DP) and to determine whether soluble …
deficient in components of the intrinsic pathway, due to a failure to activate thrombin
activatable fibrinolysis inhibitor (TAFI). This suggests the hypothesis that bleeding in
hemophilia is due not only to defective coagulation but also enhanced fibrinolysis. These
studies were carried out to quantify the extent of TAFI activation over time in normal plasma
(NP) and factor VIII deficient plasma (FVIII‐DP) and to determine whether soluble …