Key factors influencing the emergence of human immunodeficiency virus drug resistance in low-and middle-income countries
CL Wallis, C Godfrey, JE Fitzgibbon… - The Journal of …, 2017 - academic.oup.com
CL Wallis, C Godfrey, JE Fitzgibbon, JW Mellors
The Journal of infectious diseases, 2017•academic.oup.comThe emergence and spread of human immunodeficiency virus (HIV) drug resistance from
antiretroviral roll-out programs remain a threat to long-term control of the HIV-AIDS epidemic
in low-and middle-income countries (LMICs). The patterns of drug resistance and factors
driving emergence of resistance are complex and multifactorial. The key drivers of drug
resistance in LMICs are reviewed here, and recommendations are made to limit their
influence on antiretroviral therapy efficacy.
antiretroviral roll-out programs remain a threat to long-term control of the HIV-AIDS epidemic
in low-and middle-income countries (LMICs). The patterns of drug resistance and factors
driving emergence of resistance are complex and multifactorial. The key drivers of drug
resistance in LMICs are reviewed here, and recommendations are made to limit their
influence on antiretroviral therapy efficacy.
Abstract
The emergence and spread of human immunodeficiency virus (HIV) drug resistance from antiretroviral roll-out programs remain a threat to long-term control of the HIV-AIDS epidemic in low- and middle-income countries (LMICs). The patterns of drug resistance and factors driving emergence of resistance are complex and multifactorial. The key drivers of drug resistance in LMICs are reviewed here, and recommendations are made to limit their influence on antiretroviral therapy efficacy.
Oxford University Press