A prospective clinical trial combining radiation therapy with systemic immunotherapy in metastatic melanoma
SM Hiniker, SA Reddy, HT Maecker… - International Journal of …, 2016 - Elsevier
Purpose Local radiation therapy (RT) combined with systemic anti-cytotoxic T-lymphocyte–
associated protein-4 immunotherapy may enhance induction of systemic antimelanoma
immune responses. The primary objective of the present trial was to assess the safety and
efficacy of combining ipilimumab with RT in patients with stage IV melanoma. The secondary
objectives included laboratory assessment of induction of antimelanoma immune
responses. Methods and Materials In our prospective clinical trial, 22 patients with stage IV …
associated protein-4 immunotherapy may enhance induction of systemic antimelanoma
immune responses. The primary objective of the present trial was to assess the safety and
efficacy of combining ipilimumab with RT in patients with stage IV melanoma. The secondary
objectives included laboratory assessment of induction of antimelanoma immune
responses. Methods and Materials In our prospective clinical trial, 22 patients with stage IV …