Fundamental differences in the dynamics of CNS lesion development and composition in MP4-and MOG peptide 35–55-induced experimental autoimmune …
S Kuerten, S Javeri, M Tary-Lehmann, PV Lehmann… - Clinical …, 2008 - Elsevier
Multiple sclerosis (MS) is characterized by a dynamic inflammatory process in which CNS
lesions of distinct cellular composition coexist. In particular the formation of B cell plaques
has been ascribed an important role as predictor of disease progression. Here we show that
the novel MBP-PLP fusion protein (MP4)-induced experimental autoimmune
encephalomyelitis (EAE) of C57BL/6 mice fulfils these criteria inducing differential cellular
infiltration of B cells, T cells, macrophages and granulocytes and permitting the …
lesions of distinct cellular composition coexist. In particular the formation of B cell plaques
has been ascribed an important role as predictor of disease progression. Here we show that
the novel MBP-PLP fusion protein (MP4)-induced experimental autoimmune
encephalomyelitis (EAE) of C57BL/6 mice fulfils these criteria inducing differential cellular
infiltration of B cells, T cells, macrophages and granulocytes and permitting the …