Rat microglial interleukin-3
PJ Gebicke-Haerter, K Appel, GD Taylor… - Journal of …, 1994 - Elsevier
Abstract Interleukin-3 (IL-3, multi-CSF) is a growth factor for a variety of hematopoietic
progenitor cells. Recently, microglial cells, the resident macrophages of the central nervous
system (CNS) have been shown to proliferate in the presence of IL-3 both in vivo and in
culture. Data obtained from cultured astrocytes gave rise to the hypothesis that astrocytes
synthesize the microglial growth factor. This is the first report identifying rat microglial cells
themselves as a source of IL-3. Culture media conditioned by isolated microglia enhanced …
progenitor cells. Recently, microglial cells, the resident macrophages of the central nervous
system (CNS) have been shown to proliferate in the presence of IL-3 both in vivo and in
culture. Data obtained from cultured astrocytes gave rise to the hypothesis that astrocytes
synthesize the microglial growth factor. This is the first report identifying rat microglial cells
themselves as a source of IL-3. Culture media conditioned by isolated microglia enhanced …