The cytokine signature of MOG-specific CD4 cells in the EAE of C57BL/6 mice
HH Hofstetter, AY Karulin, TG Forsthuber, PA Ott… - Journal of …, 2005 - Elsevier
Experimental allergic encephalomyelitis (EAE) is an animal model of multiple sclerosis.
While EAE is mediated by the cytokines produced by specific T cells, the cytokine signature
of these effector cells is unresolved. We tested CD4 cells from MOG peptide 35–55
immunized C57BL/6 mice for their peptide induced cytokine production on antigen
presenting cells of the respective cytokine knockout mice, or wild type mice. IL-4 and IL-6
production was seen on wild type antigen presenting cells, suggesting that IL-4 and IL-6 are …
While EAE is mediated by the cytokines produced by specific T cells, the cytokine signature
of these effector cells is unresolved. We tested CD4 cells from MOG peptide 35–55
immunized C57BL/6 mice for their peptide induced cytokine production on antigen
presenting cells of the respective cytokine knockout mice, or wild type mice. IL-4 and IL-6
production was seen on wild type antigen presenting cells, suggesting that IL-4 and IL-6 are …
