[HTML][HTML] Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax

H Kwon, L Ogle, B Benitez, J Bohuslav… - Journal of Biological …, 2005 - ASBMB
Type I human T cell leukemia virus (HTLV-I) is etiologically linked with adult T cell leukemia,
an aggressive and usually fatal expansion of activated CD4+ T lymphocytes that frequently
traffic to skin. T cell transformation induced by HTLV-I involves the action of the 40-kDa viral
Tax transactivator protein. Tax both stimulates the HTLV-I long terminal repeat and
deregulates the expression of select cellular genes by altering the activity of specific host
transcription factors, including cyclic AMP-responsive element-binding protein …