Neurocircuitry of alcohol addiction: synthesis from animal models
GF Koob - Handbook of clinical neurology, 2014 - Elsevier
Alcoholism, more generically drug addiction, can be defined as a chronically relapsing
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of
control in limiting (alcohol) intake; and (3) emergence of a negative emotional state (eg,
dysphoria, anxiety, irritability), reflecting a motivational withdrawal syndrome, when access
to the drug (alcohol) is prevented (defined here as dependence). The compulsive drug
seeking associated with alcoholism can be derived from multiple neuroadaptations, but the …
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of
control in limiting (alcohol) intake; and (3) emergence of a negative emotional state (eg,
dysphoria, anxiety, irritability), reflecting a motivational withdrawal syndrome, when access
to the drug (alcohol) is prevented (defined here as dependence). The compulsive drug
seeking associated with alcoholism can be derived from multiple neuroadaptations, but the …