Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis
ME Brown, RF Anton, R Malcolm, JC Ballenger - Biological psychiatry, 1988 - Elsevier
There has been speculation that a kindling model may have applicability to alcohol
withdrawal syndromes and seizures, suggesting that repeated alcohol withdrawals may lead
to increased severity of subsequent withdrawals. We evaluated historical and clinical
variables of a group of male alcoholics with (n= 25) and without (n= 25) alcohol withdrawal
seizures. We found that the number of detoxifications appeared to be an important variable
in the predisposition to withdrawal seizures. The withdrawal seizure group had 12 of 25 …
withdrawal syndromes and seizures, suggesting that repeated alcohol withdrawals may lead
to increased severity of subsequent withdrawals. We evaluated historical and clinical
variables of a group of male alcoholics with (n= 25) and without (n= 25) alcohol withdrawal
seizures. We found that the number of detoxifications appeared to be an important variable
in the predisposition to withdrawal seizures. The withdrawal seizure group had 12 of 25 …