[HTML][HTML] Evidence That Formation of Vimentin· Mitogen-activated Protein Kinase (MAPK) Complex Mediates Mast Cell Activation following FcεRI/CC Chemokine …
M Toda, CH Kuo, SK Borman, RM Richardson… - Journal of Biological …, 2012 - ASBMB
Accumulating evidence points to cross-talk between FcεRI and CC chemokine receptor
(CCR)-mediated signaling pathways in mast cells. Here, we propose that vimentin, a protein
comprising type III intermediate filament, participates in such cross-talk for CCL2/monocyte
chemotactic protein 1 (MCP-1) production in mast cells, which is a mechanism for allergic
inflammation. Co-stimulation via FcεRI, using IgE/antigen, and CCR1, using recombinant
CCL3/macrophage inflammatory protein-1α (MIP-1α), increased expression of …
(CCR)-mediated signaling pathways in mast cells. Here, we propose that vimentin, a protein
comprising type III intermediate filament, participates in such cross-talk for CCL2/monocyte
chemotactic protein 1 (MCP-1) production in mast cells, which is a mechanism for allergic
inflammation. Co-stimulation via FcεRI, using IgE/antigen, and CCR1, using recombinant
CCL3/macrophage inflammatory protein-1α (MIP-1α), increased expression of …