Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model

DJ Song, JY Cho, M Miller, W Strangman, M Zhang… - Clinical …, 2009 - Elsevier
Siglec-F is a sialic acid binding immunoglobulin-superfamily receptor that is highly
expressed on eosinophils. We have used a mouse model of oral egg ovalbumin (OVA)-
induced eosinophilic inflammation of the gastro-intestinal mucosa associated with diarrhea
and weight loss to determine whether administering an anti-Siglec-F antibody would reduce
levels of intestinal mucosal eosinophilic inflammation. Mice administered the anti-Siglec-F
antibody had significantly lower levels of intestinal eosinophilic inflammation, and this was …