Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils

KK Kikly, BS Bochner, SD Freeman, KB Tan… - Journal of allergy and …, 2000 - Elsevier
Background: Eosinophils, basophils, and mast cells are believed to be the central tenet cells
in allergic conditions including allergic rhinitis, asthma, and eczema. The molecular
mechanisms underlying the recruitment of these cells to sites of allergic inflammation are
poorly understood. Objectives: Our aim was to identify a common adhesion molecule that
could potentially be responsible for mediating the recruitment of the allergic cell types to the
lungs and other sites of allergy. Methods: We have cloned a sialoadhesin molecule from a …