B7-H4. Ig inhibits the development of type 1 diabetes by regulating Th17 cells in NOD mice
IF Lee, X Wang, J Hao, N Akhoundsadegh, L Chen… - Cellular …, 2013 - Elsevier
Type 1 diabetes (T1D) is an autoimmune disease characterized by immunological
destruction of insulin-producing pancreatic β-cells and subsequent hyperglycemia. The non-
obese diabetic (NOD) mouse strain spontaneously develops a disease similar to human
T1D and is commonly used as an animal model for studying this disease. We have
previously shown that the administration of B7-H4-immunoglobulin fusion protein (B7-H4.
Ig), a newly identified T-cell co-inhibitory signaling molecule, blocks the onset of diabetes in …
destruction of insulin-producing pancreatic β-cells and subsequent hyperglycemia. The non-
obese diabetic (NOD) mouse strain spontaneously develops a disease similar to human
T1D and is commonly used as an animal model for studying this disease. We have
previously shown that the administration of B7-H4-immunoglobulin fusion protein (B7-H4.
Ig), a newly identified T-cell co-inhibitory signaling molecule, blocks the onset of diabetes in …