[HTML][HTML] Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative …

C Latouche, SE Heywood, SL Henry, M Ziemann… - The Journal of …, 2014 - Elsevier
Children of obese mothers have increased risk of metabolic syndrome as adults. Here we
report the effects of a high-fat diet in the absence of maternal obesity at conception on
skeletal muscle metabolic and transcriptional profiles of adult male offspring. Female
Sprague Dawley rats were fed a diet rich in saturated fat and sucrose [high-fat diet (HFD):
23.5% total fat, 9.83% saturated fat, 20% sucrose wt: wt] or a normal control diet [(CD) 7%
total fat, 0.5% saturated fat, 10% sucrose wt: wt] for the 3 wk prior to mating and throughout …