Differential changes in TGF-β/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome
M Ricci, B Mohapatra, A Urbiztondo, RJ Birusingh… - Journal of cardiac …, 2010 - Elsevier
BACKGROUND: Hypoplastic left heart syndrome (HLHS) is characterized by
underdevelopment of the left ventricle (LV) and increased biomechanical stress on the right
ventricle (RV) from single ventricle physiology. Despite the clinical significance, the
signaling pathways active during RV remodeling and disease progression are not known.
To address this, we examined differential changes in expression of genes associated with
transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signaling in RV …
underdevelopment of the left ventricle (LV) and increased biomechanical stress on the right
ventricle (RV) from single ventricle physiology. Despite the clinical significance, the
signaling pathways active during RV remodeling and disease progression are not known.
To address this, we examined differential changes in expression of genes associated with
transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signaling in RV …