Glucose tolerance, insulin sensitivity, and the homeostasis model assessment method/Response

TW van Haeften, K Matsumoto, M Yano, Y Ueki… - Diabetes …, 1998 - search.proquest.com
TW van Haeften, K Matsumoto, M Yano, Y Ueki, S Miyake
Diabetes Care, 1998search.proquest.com
Matsumoto et al.(1) have recently published an impressive study of oral glucose tolerance
test (OGTT) data from obese and nonobese Japanese subjects. They studied insulin
secretion and insulin sensitivity findings derived from OGTT data and homeostasis model
assessment (HOMA).As they described briefly in the METHODS section, insulin resistance
(R) was assessed as the R determined with HOMA, with R= insulin/(22.5 e^ sup-ln
glucose^). However, simple mathematics dictate that this calculation is identical to (insulin x …
Matsumoto et al.(1) have recently published an impressive study of oral glucose tolerance test (OGTT) data from obese and nonobese Japanese subjects. They studied insulin secretion and insulin sensitivity findings derived from OGTT data and homeostasis model assessment (HOMA).
As they described briefly in the METHODS section, insulin resistance (R) was assessed as the R determined with HOMA, with R= insulin/(22.5 e^ sup-ln glucose^). However, simple mathematics dictate that this calculation is identical to (insulin x glucose)/22.5.
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