[HTML][HTML] The role of the immune cells in fracture healing
Purpose of review Bone fracture healing is a complex physiological process relying on
numerous cell types and signals. Inflammatory factors secreted by immune cells help to
control recruitment, proliferation, differentiation, and activation of hematopoietic and
mesenchymal cells. Within this review we will discuss the functional role of immune cells as
it pertains to bone fracture healing. In doing so, we will outline the cytokines secreted and
their effects within the healing fracture callus. Recent findings Macrophages have been …
numerous cell types and signals. Inflammatory factors secreted by immune cells help to
control recruitment, proliferation, differentiation, and activation of hematopoietic and
mesenchymal cells. Within this review we will discuss the functional role of immune cells as
it pertains to bone fracture healing. In doing so, we will outline the cytokines secreted and
their effects within the healing fracture callus. Recent findings Macrophages have been …
Purpose of review
Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In doing so, we will outline the cytokines secreted and their effects within the healing fracture callus.
Recent findings
Macrophages have been found to play an important role in fracture healing. These immune cells signal to other cells of the fracture callus, modulating bone healing.
Summary
Cytokines and cellular signals within fracture healing continue to be studied. The findings from this work have helped to reinforce the importance of osteoimmunity in bone fracture healing. Owing to these efforts, immunomodulation is emerging as a potential therapeutic target to improve bone fracture healing.
Springer