Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells
T Kimitsuki, T Nakagawa, K Hisashi, S Komune… - Hearing research, 1993 - Elsevier
The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical
transduction (MET) current were investigated with a whole-cell patch-electrode voltage
clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET
channel in a dose-and voltage-dependent manner. At-50 mV, CDDP blocked the MET
channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×
10− 3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage …
transduction (MET) current were investigated with a whole-cell patch-electrode voltage
clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET
channel in a dose-and voltage-dependent manner. At-50 mV, CDDP blocked the MET
channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5×
10− 3 M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage …