Glial cell line–derived neurotrophic factor and its receptor ret is a novel ligand-receptor complex critical for survival response during podocyte injury
CC Tsui, SJ Shankland… - Journal of the American …, 2006 - journals.lww.com
Glomerulosclerosis correlates with a reduction in podocyte number that occurs through
mechanisms that include apoptosis. Whether glial cell line–derived neurotrophic factor
(GDNF), a growth factor that is critical for neural and renal development, is a survival factor
for injured podocytes was investigated. Ret, the GDNF receptor tyrosine kinase, was
upregulated in podocytes in the passive Heymann nephritis and puromycin
aminonucleoside (PA) nephrosis rat models of podocyte injury. In addition, Ret mRNA and …
mechanisms that include apoptosis. Whether glial cell line–derived neurotrophic factor
(GDNF), a growth factor that is critical for neural and renal development, is a survival factor
for injured podocytes was investigated. Ret, the GDNF receptor tyrosine kinase, was
upregulated in podocytes in the passive Heymann nephritis and puromycin
aminonucleoside (PA) nephrosis rat models of podocyte injury. In addition, Ret mRNA and …