Attachment of Toxoplasma gondii to host cells involves major surface protein, SAG-1 (P-30)
JR Mineo, LH Kasper - Experimental parasitology, 1994 - Elsevier
Previous observations have demonstrated that monoclonal and polyclonal antibodies
directed at SAG-1, the major surface protein of Toxoplasma gondii, decreased the number of
T. gondii that infected fibroblast monolayers. Direct evaluation of parasite-host cell
attachment using glutaraldehyde-fixed human fibroblasts and live tachyzoites was
performed to determine whether SAG-1 was a ligand for the host cell receptor. The
interaction between the fixed cells and T. gondii was specific and saturable as determined …
directed at SAG-1, the major surface protein of Toxoplasma gondii, decreased the number of
T. gondii that infected fibroblast monolayers. Direct evaluation of parasite-host cell
attachment using glutaraldehyde-fixed human fibroblasts and live tachyzoites was
performed to determine whether SAG-1 was a ligand for the host cell receptor. The
interaction between the fixed cells and T. gondii was specific and saturable as determined …