Toxoplasma gondii HLA-B* 0702-restricted GRA720-28 peptide with adjuvants and a universal helper T cell epitope elicits CD8+ T cells producing interferon-γ and …
H Cong, EJ Mui, WH Witola, J Sidney, J Alexander… - Human immunology, 2012 - Elsevier
The ability of CD8+ T cells to act as cytolytic effectors and produce interferon-γ (IFN-γ) was
demonstrated to mediate resistance to Toxoplasma gondii in murine models because of the
recognition of peptides restricted by murine major histocompatibility complex (MHC) class I
molecules. However, no T gondii–specific HLA-B07-restricted peptides were proven
protective against T gondii. Recently, 2 T gondii–specific HLA-B* 0702-restricted T cell
epitopes, GRA720-28 (LPQFATAAT) and GRA327-35 (VPFVVFLVA), displayed high-affinity …
demonstrated to mediate resistance to Toxoplasma gondii in murine models because of the
recognition of peptides restricted by murine major histocompatibility complex (MHC) class I
molecules. However, no T gondii–specific HLA-B07-restricted peptides were proven
protective against T gondii. Recently, 2 T gondii–specific HLA-B* 0702-restricted T cell
epitopes, GRA720-28 (LPQFATAAT) and GRA327-35 (VPFVVFLVA), displayed high-affinity …