Genetic analysis of influences on survival following Toxoplasmagondii infection
J Johnson, Y Suzuki, D Mack, E Mui, R Estes… - International journal for …, 2002 - Elsevier
Survival of mice during the acute stage of Toxoplasmagondii infection was not influenced by
the MHC Class I gene, Ld, but was influenced by the MHC Class II genes, Ia and Ie. As
unexplained variability was noted in our initial studies of influence of the Ld gene on
survival, influence of the Ld gene region on survival in the presence of a number of variables
was studied. Although route of administration and dose of parasites, and age and gender of
the mice markedly influenced outcome of T. gondii infection, the Class I Ld gene did not …
the MHC Class I gene, Ld, but was influenced by the MHC Class II genes, Ia and Ie. As
unexplained variability was noted in our initial studies of influence of the Ld gene on
survival, influence of the Ld gene region on survival in the presence of a number of variables
was studied. Although route of administration and dose of parasites, and age and gender of
the mice markedly influenced outcome of T. gondii infection, the Class I Ld gene did not …