Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis
GM Bell, AE Anderson, J Diboll, R Reece… - Annals of the rheumatic …, 2017 - Elsevier
Objectives To assess the safety of intra-articular (IA) autologous tolerogenic dendritic cells
(tolDC) in patients with inflammatory arthritis and an inflamed knee; to assess the feasibility
and acceptability of the approach and to assess potential effects on local and systemic
disease activities. Methods An unblinded, randomised, controlled, dose escalation Phase I
trial. TolDC were differentiated from CD14+ monocytes and loaded with autologous synovial
fluid as a source of autoantigens. Cohorts of three participants received 1× 10 6, 3× 10 6 or …
(tolDC) in patients with inflammatory arthritis and an inflamed knee; to assess the feasibility
and acceptability of the approach and to assess potential effects on local and systemic
disease activities. Methods An unblinded, randomised, controlled, dose escalation Phase I
trial. TolDC were differentiated from CD14+ monocytes and loaded with autologous synovial
fluid as a source of autoantigens. Cohorts of three participants received 1× 10 6, 3× 10 6 or …
