[HTML][HTML] Direct transcriptional regulation of RelB by 1α, 25-dihydroxyvitamin D3 and its analogs: physiologic and therapeutic implications for dendritic cell function
X Dong, T Craig, N Xing, LA Bachman, CV Paya… - Journal of Biological …, 2003 - ASBMB
The nuclear factor-κB (NF-κB) protein RelB plays a unique role in dendritic cell (DC) function
and, as such, is an important regulator of antigen presentation and immune regulation. In
this study, inhibition of RelB expression in DCs exposed to an analog of the active form of
vitamin D 3 (1α, 25-dihydroxyvitamin D 3 (1α, 25-(OH) 2 D 3)) was observed and shown to
be mediated by the vitamin D receptor (VDR). Potential vitamin D response elements were
identified within promoter regions of human and mouse relB genes. In gel shift experiments …
and, as such, is an important regulator of antigen presentation and immune regulation. In
this study, inhibition of RelB expression in DCs exposed to an analog of the active form of
vitamin D 3 (1α, 25-dihydroxyvitamin D 3 (1α, 25-(OH) 2 D 3)) was observed and shown to
be mediated by the vitamin D receptor (VDR). Potential vitamin D response elements were
identified within promoter regions of human and mouse relB genes. In gel shift experiments …