Tumor escape mechanism governed by myeloid-derived suppressor cells
S Nagaraj, DI Gabrilovich - Cancer research, 2008 - AACR
S Nagaraj, DI Gabrilovich
Cancer research, 2008•AACRT-cell nonresponsiveness is a critical factor in immune escape and myeloid-derived
suppressor cells play a major role in organizing this phenomenon. Recent findings indicate
that myeloid-derived suppressor cells can induce antigen-specific CD8+ T-cell tolerance
through a posttranslation mechanism which involves modification (nitration) of CD8 and the
T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance
offers new opportunities for therapeutic corrections of immune escape in cancer.[Cancer …
suppressor cells play a major role in organizing this phenomenon. Recent findings indicate
that myeloid-derived suppressor cells can induce antigen-specific CD8+ T-cell tolerance
through a posttranslation mechanism which involves modification (nitration) of CD8 and the
T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance
offers new opportunities for therapeutic corrections of immune escape in cancer.[Cancer …
Abstract
T-cell nonresponsiveness is a critical factor in immune escape and myeloid-derived suppressor cells play a major role in organizing this phenomenon. Recent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8+ T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer. [Cancer Res 2008;68(8):2561–63]
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