CD14highCD16+ rather than CD14lowCD16+ monocytes correlate with disease progression in chronic HIV-infected patients

J Han, B Wang, N Han, Y Zhao, C Song… - JAIDS Journal of …, 2009 - journals.lww.com
J Han, B Wang, N Han, Y Zhao, C Song, X Feng, Y Mao, F Zhang, H Zhao, H Zeng
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2009journals.lww.com
Objective: CD14+ CD16+ monocytes are an important cellular target for HIV-1 entry and
expand in the peripheral blood of HIV-infected individuals. Because CD14+ CD16+
monocytes are a heterogeneous population and consist of CD14 high CD16+ and CD14 low
CD16+ subsets, we evaluated the effects of HIV infection on distinct subsets of CD16+
monocytes. Methods: Untreated HIV-infected patients were recruited to investigate the
relationship between the proportions of monocyte subsets with plasma viral loads and CD4+ …
Abstract
Objective:
CD14+ CD16+ monocytes are an important cellular target for HIV-1 entry and expand in the peripheral blood of HIV-infected individuals. Because CD14+ CD16+ monocytes are a heterogeneous population and consist of CD14 high CD16+ and CD14 low CD16+ subsets, we evaluated the effects of HIV infection on distinct subsets of CD16+ monocytes.
Methods:
Untreated HIV-infected patients were recruited to investigate the relationship between the proportions of monocyte subsets with plasma viral loads and CD4+ T-cell counts. Patients receiving highly active antiretroviral therapy (HAART) were followed up in a cross-sectional and a longitudinal study.
Results:
Compared with CD14 low CD16+, CD14 high CD16+ monocytes showed higher levels of CD64 and HLA-DR antigens, which imply that these 2 distinct subsets have different immunoregulatory phenotypes. In HAART-naive patients, elevated proportions of CD14 high CD16+ monocytes were correlated with increased viral loads and decreased CD4+ T-cell counts, whereas CD14 low CD16+ monocytes did not show such correlation with disease progression. Of importance, HAART recovered the proportion of CD14 high CD16+ monocytes, whereas CD14 low CD16+ monocytes did not decrease during 1 year of antiviral therapy.
Conclusions:
Taken together, our observations elucidate distinct immune responses of monocyte subsets during HIV infection and antiviral therapy and provide new insight into the roles of innate immunity in HIV-related pathogenesis.
Lippincott Williams & Wilkins