[HTML][HTML] Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload
I Koskivirta, Z Kassiri, O Rahkonen, R Kiviranta… - Journal of biological …, 2010 - ASBMB
Tissue inhibitor of metalloproteinases 4 (TIMP4) is expressed highly in heart and found
dysregulated in human cardiovascular diseases. It controls extracellular matrix remodeling
by inhibiting matrix metalloproteinases (MMPs) and is implicated in processes including cell
proliferation, apoptosis, and angiogenesis. Timp4-deficient mice (Timp4−/−) were generated
to assess TIMP4 function in normal development and in models of heart disease. We
deleted exons 1–3 of the Timp4 gene by homologous recombination. Timp4−/− mice are …
dysregulated in human cardiovascular diseases. It controls extracellular matrix remodeling
by inhibiting matrix metalloproteinases (MMPs) and is implicated in processes including cell
proliferation, apoptosis, and angiogenesis. Timp4-deficient mice (Timp4−/−) were generated
to assess TIMP4 function in normal development and in models of heart disease. We
deleted exons 1–3 of the Timp4 gene by homologous recombination. Timp4−/− mice are …