Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
Nature, 1986•nature.com
Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are
injected with combinations of the bovine α-, β-, γ-and δ-or the α-, β-, γ-and ε-subunit-specific
messenger RNAs. The conductance and gating properties of the two classes of channels, in
conjunction with the developmental changes in the muscular contents of the mRNAs,
suggest that replacement of the γ-subunit by the ε-subunit is responsible for the functional
alteration of the receptor during muscle development.
injected with combinations of the bovine α-, β-, γ-and δ-or the α-, β-, γ-and ε-subunit-specific
messenger RNAs. The conductance and gating properties of the two classes of channels, in
conjunction with the developmental changes in the muscular contents of the mRNAs,
suggest that replacement of the γ-subunit by the ε-subunit is responsible for the functional
alteration of the receptor during muscle development.
Abstract
Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine α-, β-, γ- and δ- or the α-, β-, γ- and ε-subunit-specific messenger RNAs. The conductance and gating properties of the two classes of channels, in conjunction with the developmental changes in the muscular contents of the mRNAs, suggest that replacement of the γ-subunit by the ε-subunit is responsible for the functional alteration of the receptor during muscle development.
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