Effect of food on the absorption of vigabatrin.
M Frisk‐Holmberg, P Kerth… - British Journal of Clinical …, 1989 - Wiley Online Library
M Frisk‐Holmberg, P Kerth, PH Meyer
British Journal of Clinical Pharmacology, 1989•Wiley Online Library1. This study, involving eight healthy volunteers, revealed that food intake does not have a
clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state
showed low inter‐individual variation. 3. The plasma concentration vs time profile followed a
bi‐exponential decline with a terminal half‐life of 6.8 h and a relative bioavailability of 92%+/‐
11%. 4. In the clinical setting, vigabatrin may be taken at times convenient for the patient.
clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state
showed low inter‐individual variation. 3. The plasma concentration vs time profile followed a
bi‐exponential decline with a terminal half‐life of 6.8 h and a relative bioavailability of 92%+/‐
11%. 4. In the clinical setting, vigabatrin may be taken at times convenient for the patient.
1. This study, involving eight healthy volunteers, revealed that food intake does not have a clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state showed low inter‐individual variation. 3. The plasma concentration vs time profile followed a bi‐exponential decline with a terminal half‐life of 6.8 h and a relative bioavailability of 92% +/‐ 11%. 4. In the clinical setting, vigabatrin may be taken at times convenient for the patient.
Wiley Online Library