Analysis of naive lung CD4 T cells provides evidence of functional lung to lymph node migration
SM Caucheteux, P Torabi-Parizi… - Proceedings of the …, 2013 - National Acad Sciences
SM Caucheteux, P Torabi-Parizi, WE Paul
Proceedings of the National Academy of Sciences, 2013•National Acad SciencesThe proportion of CD4 T cells with phenotypic and functional properties of naïve cells out of
total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a
sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a
delay of∼ 14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin
prevents entry of naïve CD4 T cells into the lung. Based on treatment with anti-CD62L and
the use of CCR7−/− cells, lung naïve CD4 T cells appear to migrate to the mediastinal lymph …
total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a
sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a
delay of∼ 14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin
prevents entry of naïve CD4 T cells into the lung. Based on treatment with anti-CD62L and
the use of CCR7−/− cells, lung naïve CD4 T cells appear to migrate to the mediastinal lymph …
The proportion of CD4 T cells with phenotypic and functional properties of naïve cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of ∼14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin prevents entry of naïve CD4 T cells into the lung. Based on treatment with anti-CD62L and the use of CCR7−/− cells, lung naïve CD4 T cells appear to migrate to the mediastinal lymph nodes along a CD62L-independent, CCR7-dependent pathway. Cells that have entered the node in this manner are competent to respond to antigen. Thus, a portion (approximately one-half) of naïve CD4 T cells appears to enter the mediastinal lymph nodes through a blood-to-lung-to-lymph node route.
National Acad Sciences