Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant
LLN Hubbard, MN Ballinger, CA Wilke… - Experimental lung …, 2008 - Taylor & Francis
LLN Hubbard, MN Ballinger, CA Wilke, BB Moore
Experimental lung research, 2008•Taylor & FrancisThe authors compared efficiency of alveolar macrophage (AM) reconstitution from donor
bone marrow post transplant following 4 chemotherapy conditioning regimens and 2 total
body irradiation (TBI) regimens. TBI regimens are more effective in inducing AM
reconstitution from donor marrow. However, mice conditioned with 13 Gy split-dose TBI or a
dual-chemotherapy regimen (25 mg/kg busulfan× 4 days plus cyclophosphamide 100
mg/kg× 2 days) both demonstrate significant AM repopulation from donor marrow …
bone marrow post transplant following 4 chemotherapy conditioning regimens and 2 total
body irradiation (TBI) regimens. TBI regimens are more effective in inducing AM
reconstitution from donor marrow. However, mice conditioned with 13 Gy split-dose TBI or a
dual-chemotherapy regimen (25 mg/kg busulfan× 4 days plus cyclophosphamide 100
mg/kg× 2 days) both demonstrate significant AM repopulation from donor marrow …
The authors compared efficiency of alveolar macrophage (AM) reconstitution from donor bone marrow post transplant following 4 chemotherapy conditioning regimens and 2 total body irradiation (TBI) regimens. TBI regimens are more effective in inducing AM reconstitution from donor marrow. However, mice conditioned with 13 Gy split-dose TBI or a dual-chemotherapy regimen (25 mg/kg busulfan × 4 days plus cyclophosphamide 100 mg/kg × 2 days) both demonstrate significant AM repopulation from donor marrow. Additionally, both protocols resulted in impaired pulmonary host defense associated with overproduction of prostaglandin E2 and I2 by AMs and impaired AM phagocytosis post bone marrow transplant.
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