[HTML][HTML] Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and …

AB Versluys, JWA Rossen, B van Ewijk… - Biology of Blood and …, 2010 - Elsevier
AB Versluys, JWA Rossen, B van Ewijk, R Schuurman, MB Bierings, JJ Boelens
Biology of Blood and Marrow Transplantation, 2010Elsevier
Alloimmune lung syndromes (allo-LS), including idiopathic pneumonia syndrome,
bronchiolitis obliterans syndrome, and bronchiolitis obliterans organizing pneumonia, are
severe complications after hematopoietic stem cell transplantation (HSCT). In our cohort of
110 pediatric patients, 30 had allo-LS (27.3%), 18 with ideopathic pneumonia syndrome and
12 with bronchiolitis obliterans syndrome. Multivariate analysis showed that respiratory viral
infection early after HSCT is an important predictor for the development of allo-LS (P< …
Alloimmune lung syndromes (allo-LS), including idiopathic pneumonia syndrome, bronchiolitis obliterans syndrome, and bronchiolitis obliterans organizing pneumonia, are severe complications after hematopoietic stem cell transplantation (HSCT). In our cohort of 110 pediatric patients, 30 had allo-LS (27.3%), 18 with ideopathic pneumonia syndrome and 12 with bronchiolitis obliterans syndrome. Multivariate analysis showed that respiratory viral infection early after HSCT is an important predictor for the development of allo-LS (P <.0001). This was true for all viruses tested. In multivariate analysis, allo-LS was the only predictor for higher mortality (P = .04). Paradoxically, prolonged administration of immunosuppressive agents because of acute graft-versus-host disease had a protective effect on the development of allo-LS (P = .004). We hypothesize that early infection of the respiratory tract with a common cold virus makes the lungs a target for alloimmunity.
Elsevier